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KMID : 0617319940040010067
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Journal of Pharmacetical Sceiences Ewha Womans University
1994 Volume.4 No. 1 p.67 ~ p.71
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Controlled Release of Drugs from Reservoir Type Devices Coated with Porous Polyurethane Membranes
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Abstract
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Reservoir type devices were designed for long-term implantable drug delivery system. The reservoir type device was prepared with the polymethacrylic acid gel coated with polyurethane membrane. Release controlling agent (RCA) were employed to control drug release from devices via generation of micropores in the membranes. The polyurethane membrane functioned as a rate controlling barrier. The drug release pattern of hydrogel demonstrated zero order kinetics. The release rate of drugs could be regulated by varying hydrophobicity/hydrophilicity and content of the RCA, as well as the thickness of the polyurethane membrane. The release of drugs from this system was governed by pore mechanism via simple diffusion and osmotic pressure.
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